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Fu, H. and Zhang, B. Effect of xuezhikang on hyperlipidemia of chronic renal failure patients with peritoneal dialysis. There, it is eliminated from the body. How Do Statin Drugs Work? Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Discuss specific use of drug and side effects with patient as it relates to treatment. HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Ethel Siris, MD: Let's talk about calcium and vitamin D. Everybody needs enough. If you're already getting enough from your diet, you don't take extra. It won't help. What if you're not getting enough?

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Etravirine: May decrease the serum concentration of HMG-CoA Reductase Inhibitors. This applies to atorvastatin, lovastatin and simvastatin. Conversely, levels of fluvastatin may be increased. Management: Dose adjustment of the HMG-CoA reductase inhibitor may be warranted. No interaction is expected with rosuvastatin, pravastatin, or pitavastatin. Hyperlipidemia: Secondary causes of hyperlipidemia should be ruled out prior to therapy. Some drugs, such as and progestins, can increase the "bad" cholesterol and decrease the "good" cholesterol. Consuming large amounts of grapefruit juice increases serum levels of simvastatin by up to three-fold, increasing the risk of side effects. The FDA recommends that people taking statins should avoid consuming more than a quart of grapefruit juice per day.

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Sindrup, S. H. Statins and peripheral neuropathy. Eur. Fazio, S. Effects of a nutraceutical combination berberine, red yeast rice and policosanols on lipid levels and endothelial function randomized, double-blind, placebo-controlled study. Nutr Metab Cardiovasc. Patrick McBride, MD, MPH, director of the cholesterol clinic at the University of Wisconsin School of Medicine and Public Health.

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The information contained in the Truven Health Micromedex products as delivered by Drugs. Heber, D. Plasma clearance of lovastatin versus chinese red yeast rice in healthy volunteers. If nausea, vomiting, or diarrhea occurs, ask your doctor for ways to lessen these effects. Contact your doctor right away if you experience severe or persistent diarrhea, nausea, or vomiting.



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Alberts, A. W. The effects of mevinolin on serum cholesterol levels of rabbits with endogenous hypercholesterolemia. Here is information you can use to help you decide what types of massage will work best for you. Which Massage Styles Are Best? Simvastatin Oral Suspension and call their healthcare professional. Use and dose must be determined by your doctor. May be administered without regard to meals. Administer in the evening for maximal efficacy. PREGNANCY and BREAST-FEEDING: Do not use simvastatin if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if this medicine is found in breast milk. Do not breast-feed while taking simvastatin. Chen ZM. Comparison of the therapeutic effects of simvastatin and Zhibituo for treatment of hyperlipidemia. If patient develops a confusional state or memory impairment, may evaluate patient for nonstatin causes eg, exposure to other drugs systemic and neuropsychiatric causes, and the possibility of adverse effects associated with statin therapy. This kicks in the liver's impulse to gather cholesterol the body needs from the bloodstream, reducing the chance it will add to dangerous plaque deposits. His shift is at the of a simmering debate in medicine over statins. And it comes at a time when statins -- one of the most commonly prescribed medications in this country, taken by an estimated 1 in 4 middle-aged adults -- may become even more widely used. New guidelines, introduced last November, could push that number to as many as 1 in 2 adults over age 40, according to a recent analysis in the New England Journal of Medicine.



What conditions does simvastatin treat

Dosage adjustment with concomitant medications: With concomitant amiodarone, amlodipine, diltiazem, dronedarone, lomitapide, ranolazine, or verapamil: Refer to adult dosing. Other medications can affect the removal of simvastatin from your body, which may affect how simvastatin works. Examples include certain azole antifungals such as itraconazole, ketoconazole, posaconazole, voriconazole boceprevir, cobicistat, colchicine, delavirdine, macrolide antibiotics such as clarithromycin, erythromycin nefazodone, HIV protease inhibitors such as nelfinavir, ritonavir telaprevir, telithromycin, among others. Soluble fiber -- available in supplements such as as well as in food -- can lower LDL cholesterol. Body as a whole - general disorders: fatigue. Wang SH, Sun JL Liu HQ. Therapeutic observations of Xuezhikang for treatment of 60 cases of elderly with hyperlipidemia. The work inside your intestine. They attach to bile from the liver and prevent it from being absorbed back into your blood. Bile is made largely from cholesterol, so these drugs whittle down the body's supply of cholesterol. Teng, S. S. and Feldheim, W. Anka and anka pigment production. J Ind Microbiol. Pharmaceuticals Ltd. United Kingdom GBN. Amiodarone: May increase the serum concentration of Simvastatin. Management: Consider using a non-interacting statin pravastatin in patients on amiodarone. If combined, limit the simvastatin dose to 20 mg daily and monitor for evidence of simvastatin toxicities eg, myalgia, liver function test elevations, rhabdomyolysis. Martino, F. The treatment of hypercholesterolemic children: efficacy and safety of a combination of red yeast rice extract and policosanols. Nutr. CHILDREN younger than 10 years old; safety and effectiveness in these children have not been confirmed. LDL or if such treatments are unavailable. Rarely, statins may cause or worsen diabetes. Talk to your doctor about the benefits and risks. Side Effects List Simvastatin side effects by likelihood and severity. Simvastatin has important interactions with juice and other drugs, including some that are commonly used for the treatment of cardiovascular disease. July 23-30, 2003; vol 290: pp 502-510.



What is simvastatin

Simeprevir: May increase the serum concentration of Simvastatin. American Heart Association recommended low-fat meal. Cong B. Observations on the therapeutic effects of Zhibituo for treatment of hyperlipidemia. Suspension with an accurate measuring device. Gu ZY, Lu ZF Zhu HQ. Observations on the therapeutic effects of Zhibituo for treatment of 158 patients with hyperlipidemia. Therapeutic Research Faculty 2009. Simvastatin can be taken with or without food. Patients with these conditions may be at risk for muscle or kidney problems. Li, J. P. Effect of Xuezhikang Capsule on serum tumor necrosis factor-alpha and interleukin-6 in patients with nonalcoholic fatty liver disease and hyperlipidemia. It is also used to decrease the risk of heart problems in those at high risk. It is taken by mouth. Using simvastatin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Palmucci, L. Chinese red rice depletes muscle coenzyme Q10 and maintains muscle damage after discontinuation of statin treatment. Store colchicine at room temperature, between 68 and 77 degrees F 20 and 25 degrees C in a tightly closed container. Store away from heat, light, and moisture. Do not store in the bathroom. Keep colchicine out of the reach of children and away from pets. Retrieved 14 January 2015. Li, Y. L. Xuezhikang, an extract of cholestin, protects endothelial function through antiinflammatory and lipid-lowering mechanisms in patients with coronary heart disease.



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Surgical patients: The manufacturer recommends temporary discontinuation for elective major surgery, acute medical or surgical conditions, or in any patient experiencing an acute or serious condition predisposing to renal failure eg, sepsis, hypotension, trauma, uncontrolled seizures. Based on current research and clinical guidelines Fleisher, 2009 HMG-CoA reductase inhibitors should be continued in the perioperative period. Postoperative discontinuation of statin therapy is associated with an increased risk of cardiac morbidity and mortality. Goma, G. Pigments of Monascus. The optimal age at which to initiate lipid-lowering therapy to decrease the risk of symptomatic adulthood CAD has not been determined. Shen MY. Comparison of the effects of Xuezhikang and atorvastatin for treatment of hyperlipidemia. Shake the oral suspension well for at least 20 seconds before using it. Use a marked measuring spoon, oral syringe, or medicine cup to measure the right dose. Li, H. Effect of xuezhikang on alpha1- and beta2-microglobulin in patients with essential hypertension. In bad cases of scoliosis or kyphosis, a person may have a hard time breathing. VYTORIN passes into your breast milk. The FDA warning, released again on June 8, 2011, suggested that high dose "simvastatin should be used only in patients who have been taking this dose for 12 months or more without evidence of muscle injury" and that it "should not be started in new patients, including patients already taking lower doses of the drug. Piscitelli SC, Burstein AH, Chaitt D, et al. Indinavir concentrations and St John's wort. Lai, M. M. Efficacy and safety of Monascus purpureus Went rice in subjects with hyperlipidemia.



What Are Possible Side Effects of Zocor?

This drug may rarely cause muscle problems which can rarely lead to very serious conditions called and autoimmune myopathy. Retterstol, K. HypoCol red yeast rice lowers plasma cholesterol - a randomized placebo controlled study. Scand. In the primary intent-to-treat analysis, 639 15. Huang YL, Zhou JG Zhang HF Shi YX Wang MS. Comparison of the therapeutic effects of simvastatin and Zhibituo for the elderly with hyperlipidemia. China Coronary Secondary Prevention Study Group. China coronary secondary prevention study CCSPS. Lipid regulating therapy with xuezhikang for secondary prevention of coronary heart disease. Lu, Z. The clinical examinations of Xue-Zhi-Kang in the treatment for hypercholesterolemia. Chen L, Qin YW Zheng X. Effects of lipid modification of Diao Zhibituo capsules. Continued What Are the Health Benefits of Massage? If you experience any unexplained joint or muscle pain, tenderness, or weakness while taking statins, you should call your doctor immediately. Pregnant women or those with active or chronic liver disease should not use statins.



Simvastatin ingredients

How is High Blood Cholesterol Treated? Fusidic Acid Systemic: May increase the serum concentration of CYP3A4 Substrates. QuiNINE: May increase the serum concentration of HMG-CoA Reductase Inhibitors. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. Simvastatin is effective alone or in combination with bile acid sequestrants. Dosing should occur either more than 2 hours before or more than 4 hours after administration of bile acid sequestrants. Using simvastatin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Xu SG. Analysis of therapeutic effect of Xuezhikang for treatment of primary hypercholesterolemia.



What other drugs will affect simvastatin

Use with caution. May cause side effects to become worse. Liver problems: Red yeast contains chemicals that are the same as the statin drug lovastatin. Lovastatin can cause liver damage. Some research shows that red yeast might also cause liver damage. However, other research shows that red yeast might improve liver function in people with certain liver problems. Because of the mixed results, red yeast products should be used cautiously or avoided in people with liver problems. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Continued How Do I Find Out What My Cholesterol Numbers Are and What They Mean? Li BH, Zheng GJ Zhang WG Xu M Ren P. Clinical observations of Ruanmaijianzhi capsule in the treatment of dyslipidemia. Zheng H, Dan XY Ning H Xue B. Observations of Xuezhikang on clinical effects and haemorheology. Yu HY, Li TH. Observations on the therapeutic effects of Zhibituo for treatment of hyperlipidemia. Simvastatin was initially marketed by under the trade name Zocor, but is available generically in most countries following the patent expiry.



Use of simvastatin

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Contact your doctor or health care provider right away if any of these apply to you. Red yeast can help lower cholesterol. Taking red yeast along with other medications used to lower cholesterol might increase the risk of adverse effects. Do not take red yeast if you are already taking medications used for lowering cholesterol. The and fiber in nuts make them very filling. Pan, T. M. In vivo hypolipidemic effects and safety of low dosage Monascus powder in a hamster model of hyperlipidemia. Appl. Older adults may be more sensitive to the side effects of this medication, especially muscle problems. These drugs work inside the intestine, where they bind to bile and prevent it from being reabsorbed into the circulatory system. Bile is made largely from cholesterol, so these drugs work by reducing the body's supply of cholesterol, thus lowering total and LDL cholesterol. The most common side effects are constipation, gas, and upset stomach. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Tell your doctor if you have ever had any unusual or allergic reaction to simvastatin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. The risk of muscle injury increases when certain other medications are taken with statins. For example, if you take a combination of a statin and a fibrate -- another cholesterol-reducing drug -- the risk of muscle damage increases greatly compared to someone who takes a statin alone. However, not all cholesterol is bad. It's good, for instance, to have high levels of HDL "good" cholesterol. Green Tea: May increase the serum concentration of Simvastatin. Specifically, Simvastatin lactone concentrations may be increased.



AUC0-24hr for total ezetimibe

CPK: CPK should not be routinely measured. Baseline CPK measurement is reasonable for some individuals eg, family history of statin intolerance or muscle disease, clinical presentation, concomitant drug therapy that may increase risk of myopathy. May measure CPK in any patient with symptoms suggestive of myopathy pain, tenderness, stiffness, cramping, weakness, or generalized fatigue. Passed by the chair massage section in an airport? One 2004 study of 58 adults with looked at the effects of eating a handful of walnuts each day in addition to a healthy diet. Raltegravir: May enhance the myopathic rhabdomyolysis effect of HMG-CoA Reductase Inhibitors. It is very important to continue to follow your doctor's advice about diet and exercise. It may take up to 4 weeks before you get the full benefit of this drug. Figure 1. Similarly, 526 11. It may harm them. Red yeast contains chemicals similar to the prescription drugs called "statins. Consult your doctor before breast-feeding.



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What are the possible side effects of simvastatin

It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. Call your doctor right away if you get a headache, stomach pain, vomiting, dark-colored urine, loss of appetite, weight loss, general feeling of tiredness or weakness, light-colored stools, upper right stomach pain, or yellow eyes or skin. These could be symptoms of liver damage.

How Is High Cholesterol Treated?

VYTORIN and 749 17. Eating grapefruit or drinking grapefruit juice may increase the amount of simvastatin in your blood, which may increase your risk for serious side effects. The risk may be greater with large amounts of grapefruit or grapefruit juice. Avoid large amounts of grapefruit or grapefruit juice eg, more than 1 quart daily. Talk with your doctor or pharmacist if you have questions about including grapefruit or grapefruit juice in your diet while you are taking simvastatin. Studies have shown that taking statins can lower those risks in large groups of people, but the impact on a person's individual risk is much smaller.

Important information

Take TriCor exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Tell your doctor or dentist that you take simvastatin before you receive any medical or dental care, emergency care, or surgery. Simvastatin may need to be stopped for a few days before certain types of surgery. ELDERLY; they may be more sensitive to its effects, especially muscle problems. Kuno, N. and Mizutani, T. Influence of synthetic and natural food dyes on activities of CYP2A6, UGT1A6, and UGT2B7. J Toxicol.

How should i store simvastatin

Do not consider Communities as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.

Erythromycin Systemic: May increase the serum concentration of Simvastatin. Yang MJ, Wang RZ. Zhibituo for treatment of 100 cases of hyperlipidemia. Cheng, J. T. Plasma glucose-lowering action of Hon-Chi in streptozotocin-induced diabetic rats. Horm. In 1994, publication of the results of the 4S provided the first unequivocal evidence that lowering LDL cholesterol via statin treatment reduces cardiovascular events and overall mortality. Rosano, G. Long-term effects of nutraceuticals berberine, red yeast rice, policosanol in elderly hypercholesterolemic patients. Adv.

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